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KMID : 1044720120020010041
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Journal of Lifestyle Medicine
2012 Volume.2 No. 1 p.41 ~ p.46
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Non-high-density Lipoprotein Cholesterol Is a Good Indicator of Pulse Wave Velocity rather than Low-density Lipoprotein Cholesterol in Asymptomatic Individuals
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Kwon Seon-Young
Son You-Na
Lee Ji-Won
Kim Jong-Koo
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Abstract
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Although targeting low-density lipoprotein cholesterol (LDL-C) has been a primary goal of lipid lowering therapy, a few growing evidences show that non-high-density lipoprotein cholesterol (Non-HDL-C) is a strong, independent predictor of cardiovascular disease nowadays. But few studies have assessed the association between conventional lipoproteins and subclinical atherosclerosis. We analyzed the association of Non-HDL-C, LDL-C with brachial-ankle pulse wave velocity (baPWV), a marker of subclinical atherosclerosis. We studied 766 apparently healthy individuals who checked baPWV. We analyzed P for trend for the association between baPWV and quartiles of Non-HDL-C, LDL-C. Multivariate analysis was used between quartiles of each lipoprotein and baPWV after adjustment for confounding variables. BaPWV shows increased trend across increase quartiles of Non-HDL-C and LDL-C, with statistical significance only in Non-HDL-C. In a multiple regression model, pulse wave velocity was positively correlated with Non-HDL-C and LDL-C. The relationship remained in Non-HDL-C after adjustment of LDL-C. However, in LDL-C, the relationship was vanished after adjustment of Non-HDL-C. In this study Non-HDL-C was more strongly associated with baPWV than LDL-C. These data suggests that Non-HDL-C may be an important treatment target in the prevention of cardiovascular disease.
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KEYWORD
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Pulse wave velocity, Atherosclerosis, Lipoproteins, Non-high density lipoprotein cholesterol
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